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Research: Atlanta Acupuncture Infertility

Decatur GA Acupuncture Infertility Atlanta

Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study.

Dieterle S, Ying G, Hatzmann W, Neuer A.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Witten/Herdecke, Dortmund, Germany. Dieterle@IVF-Dortmund.de

OBJECTIVE: To determine the effect of luteal-phase acupuncture on the outcome of IVF/intracytoplasmic sperm injection (ICSI).

DESIGN: Randomized, prospective, controlled clinical study.

SETTING: University IVF center.

PATIENT(S): Two hundred twenty-five infertile patients undergoing IVF/ICSI. INTERVENTION(S): In group I, 116 patients received luteal-phase acupuncture according to the principles of traditional Chinese medicine. In group II, 109 patients received placebo acupuncture. MAIN

OUTCOME MEASURE(S): Clinical and ongoing pregnancy rates. RESULT(S): In group I, the clinical pregnancy rate and ongoing pregnancy rate (33.6% and 28.4%, respectively) were significantly higher than in group II (15.6% and 13.8%).

CONCLUSION(S): Luteal-phase acupuncture has a positive effect on the outcome of IVF/ICSI.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Chinese traditional medicine yi kang ling to treat immunity infertility caused by anti-sperm antibody: the experimental research II

Dai XL, Cui YX, Wang YM, Hu YA, Xu JP, Yao B, Li BT. Department of Pharmacology, Nanjing General Hospital, Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.

Zhonghua Nan Ke Xue. 2003 Dec;9(9):713-5 [Article in Chinese]

OBJECTIVE: To observe the effects of Chinese traditional medicine Yi Kang Ling (YKL) on immunity infertility caused by anti-sperm antibodies (AsAb).

METHODS: With the AsAb infertile rabbit as the experimental model, seventy-five pairs of New zealand rabbits were divided into three group including YKL treatment group (sub-divided into mini-, midi- and maxi-dosage groups), prednisone treatment group and non-treatment group. Rabbits of the YKL treatment sub-groups were further divided into M+F- (male positive, female negative), M-F+, (male negative, female positive) and M+F+ (male positive, female positive) pairs according to their initial AsAb detection results. The control group consisted of five pairs of normal rabbits. When the expected AsAb reversing ratio was achieved, the rabbits were matted and observed for the number of the pregnant and the weight of the newborn.

RESULTS: Statistics showed that in M+F- pairs both the midi-dosage of YKL and prednisone treatment groups had fertility, in the mini- and maxi-dosage of YKL treatment groups, 20% of the female rabbits failed to be pregnant, while in the non-treatment group, 60% female rabbits remained sterile. The sterile ratios of the M-F+ pairs in the mini-, midi- and maxi-dosage of YKL and prednisone treatment groups were 0, 20%, 25% and 25%, respectively, while the sterile ratio in the non-treatment M-F+ group was 40%. In M+F+ groups, the sterile ratios of the three YKL sub-groups, prednisone treatment and non-treatment groups were 20%, 20% and 60% respectively. In the control group the sterile ratio was 20%. The weight of the newborn rabbits were around 50 grams with no visible malformation.

CONCLUSIONS: YKL can effectively reverse the AsAb positive results, and restore the fertility of female rabbits. Mini-dosage of YKL for 45 days produced the best results and maxi-dosage of YKL had no negative effects on the weight of the newborn rabbit.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

An experimental study on inhibitory effect of Chinese medicine tai-bao on antisperm antibody

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Jun;17(6):360-2 [Article in Chinese]

Lai AN, Song JF, Liu XJ. Xiyuan Hospital, China Academy of TCM, Beijing.

OBJECTIVE: To investigate whether Chinese medicine Tai-bao could inhibit antisperm antibody in experimental mice.

METHODS: The experimental immunoinfertility mice were due to antisperm antibody induced by injection of human sperm membrane antigens. The experimental immuno-infertile mice used in the present study were divided into four groups including Tai-bao high dose group (46.8 g.kg-1.d-1), Tai-bao low dose group (31.2 g.kg-1.d-1), prednisone group and normal saline group. The enzyme linked immune sorbent assay (ELISA) and microcytotoxic assay were used for detection of antisperm antibody. The change of levels of antisperm antibody before and after treatment, pregnant rate, and the number of implantation were investigated in tested mice.

RESULTS: The pregnant rates in normal saline group, prednisone group, Tai-bao high dose group and low dose were 38.89%, 47.06%, 70.00% and 75.00% respectively. The rate of pregnancy in Tai-bao low dose group was significantly higher as compared with normal saline group (P < 0.05). The rate of implantation in Tai-bao low dose group was significantly higher than that in prednisone group (P < 0.05). The results of detection of the cytotoxic antibody to sperm showed that cytotoxic percentages in Tai-bao high dose group (63.0 +/- 10.3%) and prednisone group (56.3 +/- 13.7%) were significantly lower (P < 0.05 and P < 0.01) than that in normal saline group (72.84 +/- 5.05%).

CONCLUSION: Chinese medicine Tai-bao possesses regulatory effect on reproductive immune function, inhibitory effect on antisperm cytotoxic antibody, and promoting effect on pregnancy.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

TCM treatment of infertility due to luteal phase defect--an analysis of 60 cases.

J Tradit Chin Med. 1991 Jun;11(2):115-20.
Lian F. Nanjing College of Traditional Chinese Medicine.

Sixty cases of infertility due to luteal phase defect were treated with herbs to tonify the kidney and regulate the menstrual cycle.

After the treatment, the hyperthermal phase score of basal body temperature (BBT) was markedly increased (P less than 0.05), the hyperthermal phase 7-8 days after ovulation improved (P less than 0.001), the transitional period of BBT remarkably shortened, and the pregnancy rate in 32 uncomplicated cases of luteal phase defect was 56%.

The close relationship between luteal phase defect and the kidney deficiency syndrome in TCM was discussed. The key points of the treatment included coordination of yin and yang, regulation of qi and blood, and combination of tonification with reduction.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

The improvement of luteal insufficiency in fecund women by tokishakuyakusan treatment

Usuki S, Higa TN, Soreya K. Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

The effect of tokishakuyakusan, a Chinese herbal medicine, was examined, in vivo, in women with luteal insufficiency and in women with normal menstrual cycles.

Luteal insufficiency was determined by daily measurement of basal body temperature and plasma progesterone levels. Tokishakuyakusan improved luteal insufficiency. Furthermore, the effects of tokishakuyakusan on prolactin, gonadotropins, steroids, angiotensin II, ANP and renin levels in the blood of women with normal menstrual cycles were studied, as were the medicine's effects on estrogens, pregnenediol and LH in the urine of the same women.

Tokishakuyakusan had no adverse effect on hormonal levels in either blood or urine. Furthermore, no clinical side effects were detected. These results suggest that tokishakuyakusan improves luteal insufficiency in women but does not affect the hormonal levels of women with normal menstrual cycles.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Treatment of secondary amenorrhea and oligohypomenorrhea with combined traditional Chinese and Western medicine

Ge XL. Dept. of Gynecology, Second Affiliated Hospital, Hebei Medical College, Shijiazhuang. Zhong Xi Yi Jie He Za Zhi. 1991 Nov;11(11):661-3, 645 [Article in Chinese]

This article reported the treatment of 149 cases (1087 cycles) with secondary amenorrhea and oligohypomenorrhea, including 42 cases who were treated by cycle treatment with traditional Chinese medicine (TCM) and clomiphene in comparison with clomiphene in 67 cases and/or TCM in 40 cases at the same time.

The results showed that ovulatory rate of secondary amenorrhea, calculated according to menstrual cycles, was significantly higher in the group of TCM and clomiphene than that of clomiphene or TCM (P less than 0.01). The efficacy of clomiphene was better than that of TCM (P less than 0.01). The ovulatory rate of oligohypomenorrhea was significantly increased by using TCM and clomiphene in contrast to only western medicine (P less than 0.05). The phenomena mentioned above indicate that the TCM-WM treatment has obvious advantages.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Clinical studies on the mechanism for acupuncture stimulation of ovulation

J Tradit Chin Med. 1993 Jun;13(2):115-9
Mo X, Li D, Pu Y, Xi G, Le X, Fu Z. Zhejiang College of Traditional Chinese Medicine, Hangzhou.

Ovulatory dysfunction is commonly seen in gynecology clinics. It may cause infertility, amenia, functional uterine bleeding and a variety of complications. This research according to TCM theory records treating with acupuncture 34 patients suffering from ovulatory dysfunction. Changes in clinical symptoms and some relative targets are reported, plus findings in animal experiments. The effect of acupuncture in improving ovulation and the rationale are discussed.

According to TCM theory concerning the generative and physiologic axis of women, this research involved the following points: Ganshu (UB 18), Shenshu (UB 23), Guanyuan (Ren 4), Zhongji (Ren 3), and Sanyinjiao (Sp 6). The reinforcement and reduction of acupuncture enables it to strengthen liver and kidney. Through the Chong and Ren channels it nourishes uterus to adjust the patient's axis function and recover ovulation.

Treated on an average of 30 times, the patients' symptoms improved to varying degrees. The marked effective rate was 35.29%, the total effective rate being 82.35%. BBT, VS, CMS, and B ultrasonic picture all improved to some degree.

The results also showed that acupuncture may adjust FSH, LH, and E2 in two directions and raise the progesterone level, bringing them to normal. The animal experiments confirmed this result.

Results showed that acupuncture may adjust endocrine function of the generative and physiologic axis of women, thus stimulating ovulation. The results of this research will provide some scientific basis for treating and further studying this disorder.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Effects of unkei-to, an herbal medicine, on endocrine function and Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion.

J Reprod Med. 2001 May;46(5):451-6
Ushiroyama T, Ikeda A, Sakai M, Hosotani T, Suzuki Y, Tsubokura S, Ueki M.
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. gyn003@poh.osaka-med.ac.jp

OBJECTIVE: To treat anovulatory women with high plasma LH levels with unkei-to.

STUDY DESIGN: A total of 100 patients with polycystic ovary syndrome (n = 38) or non-polycystic ovary syndrome (n = 62) were allocated randomly into two groups. Endocrine levels (FSH, LH and estradiol), follicle growth and response to unkei-to were compared for 52 subjects in the unkei-to group and 48 subjects in the control group.

RESULTS: Unkei-to induced significant decreases in plasma LH in polycystic ovary syndrome and non-polycystic ovary syndrome with high LH levels. Plasma estradiol levels increased significantly (43.5%) in eight weeks of treatment with unkei-to. Significant development of the dominant follicle was also observed in patients treated with unkei-to. When women suffering from ovulatory failure or irregular menstruation and having high plasma LH concentration were treated with unkei-to for eight weeks, a reduction in the serum LH level of at least 1 SD from baseline was noted in 45.5% of polycystic ovary syndrome patients and in 80.0% of non-polycystic ovary syndrome patients. The mean rate of reduction of serum LH was 22.2 +/- 35.7% in polycystic ovary syndrome patients and 49.7 +/- 15.3% in non-polycystic ovary syndrome patients. This reduction was significant in the non-polycystic ovary syndrome patients (P = .030). The rate of menstrual cycle improvement, including successful ovulation, was 50.0% in the polycystic ovary syndrome group and 60.0% in the non-polycystic ovary syndrome group, with no significant difference between the two groups.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Therapeutic effect of Chinese herbal medicines for nourishing blood and reinforcing shen in treating patients with anovulatory sterility of shen-deficiency type and its influence on the hemodynamics in ovarian and uterine arteries

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Apr;24(4):299-302. [Article in Chinese]
Xia YW, Cai LX, Zhang SC. Xiyuan Hospital, China Academy of TCM, Beijing 100091.

OBJECTIVE: To observe the clinical therapeutic effect of Nuzhen Yunyu Decoction (NYD, a Chinese recipe for nourishing blood and reinforcing Shen) and its influence on the hemodynamic parameters in ovarian and uterine arteries.

METHODS: Sixty-eight patients were randomly divided into two groups at the ratio of 2:1, 45 in the TCM group treated with Chinese medicine and 23 in the control group treated with clomiphene citrate. Menstrual cycle were taken as the indexes for clinical observation; basal body temperature, cervical mucus, vaginal exfoliative cells, serum hormones and B ultrasonic examination were taken as the indexes for ovulation and pregnancy assessment. The hemodynamic parameters of uterus and ovary were determined by using color Doppler ultrasonography, and the growth of follicles and ovulation, thickness of uterine endometrium were also monitored continuously.

RESULTS: Results of 3 cycles treatment and 1 year follow-up study showed that the ovulation promoting rate, pregnancy rate and abortion rate in the two groups were similar, but the treated group showed better effects than that of control group, in such aspects as regulating menstruation, promoting growth and development of follicle, strengthening endometrium, improving blood supply and circulation of uterine and ovary (P < 0.05, P < 0.01).

CONCLUSION: NYD has the effects of ovulation promotion and holistic regulation of reproductive system.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Treatment of secondary amenorrhea and oligohypomenorrhea with combined traditional Chinese and Western medicine

Ge XL. Dept. of Gynecology, Second Affiliated Hospital, Hebei Medical College, Shijiazhuang. Zhong Xi Yi Jie He Za Zhi. 1991 Nov;11(11):661-3, 645 [Article in Chinese]

This article reported the treatment of 149 cases (1087 cycles) with secondary amenorrhea and oligohypomenorrhea, including 42 cases who were treated by cycle treatment with traditional Chinese medicine (TCM) and clomiphene in comparison with clomiphene in 67 cases and/or TCM in 40 cases at the same time.

The results showed that ovulatory rate of secondary amenorrhea, calculated according to menstrual cycles, was significantly higher in the group of TCM and clomiphene than that of clomiphene or TCM (P less than 0.01). The efficacy of clomiphene was better than that of TCM (P less than 0.01). The ovulatory rate of oligohypomenorrhea was significantly increased by using TCM and clomiphene in contrast to only western medicine (P less than 0.05). The phenomena mentioned above indicate that the TCM-WM treatment has obvious advantages.

Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Clinical observation on treatment of hyperinsulinemia and hyperandrogenism anovulatory patient with replenishing kidney-yin drugs

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Sep;16(9):515-8 [Article in Chinese]
Zhou LR, Yu J. The Obstetrics and Gynecology Hospital, Shanghai Medical University.

In order to investigate the effect of Chinese herbal medicine for replenishing Kidney-Yin in treating hyperinsulinemia and hyperandrogenism anovulatory syndrome, 35 patients were treated with replenishing Kidney-Yin drugs for 3 months, basic body temperature, ultrasonic examination and blood levels of sex hormones were taken for monitoring the ovulation, and changes of serum insulin, blood sugar as well as oral glucose tolerence test were observed before and after treatment.

Thirty-five patients showed high serum insulin and testosterone levels but normal dehydroepiandrosterone (DHEA) level. Twenty-nine percent of their luteinizing hormone/folliclestimulating hormone (LH/FSH) ratio were in normal range. Twenty four cases completed the regular treatment and 20 of them showed ovulation in the 43 menstrual cycles (59.7%).

Seven of 17 (41.2%) infertile cases become pregnant within 6 months. After 3 months of treatment, blood sugar and insulin level significantly decreased but the latter was still slightly higher than normal level. Serum testosterone level decreased significantly and reached normal.

Results suggested that replenishing Kidney-Yin Drugs could provide a good microcircumstance for ovarian follicular growth, and resulted in ovulation and pregnancy. The mechanism is remained to be further explored.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Effect of TJ-68 (shakuyaku-kanzo-to) on polycystic ovarian disease.

Takahashi K, Kitao M. Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan. Int J Fertil Menopausal Stud. 1994 Mar-Apr;39(2):69-76

OBJECTIVE--To investigate the effect of an herbal medicine, Shakuyaku-Kanzo-To (TJ-68), on endocrine variables in patients with polycystic ovarian disease (PCOD).

SETTING--Medical university hospital.

PATIENTS AND INTERVENTIONS--Thirty-four Japanese women with PCOD were treated daily with 7.5 g of TJ-68 for 24 weeks. Testosterone (T), free-testosterone (free-T), sex hormone binding globulin (SHBG), LH, FSH, estrone, 17 beta-estradiol, 3,4-dihydroxyphenylglycol (DOPEG), and 3, 4-dihydroxyphenylacetic acid (DOPAC) were examined.

RESULTS--No side effects were observed in any cases. At 4 weeks after initiation of treatment, serum T and free-T levels significantly decreased, while SHBG was not significantly elevated. Meanwhile, after 12 weeks of treatment, the mean serum T level of the patients who became pregnant decreased to 35% of that before the treatment, but levels did not change in the patients who failed to conceive. There was no significant difference in estrone/estradiol ratio before and after treatment, but the estradiol/testosterone ratio increased significantly after 4 weeks of treatment. The LH/FSH ratio after 24 weeks of treatment was significantly lower than that before treatment. DOPEG and the DOPEG/DOPAC ratio significantly decreased after 4 weeks of treatment.

CONCLUSIONS--It is suggested that TJ-68 acts directly on the ovary first, increasing the activity of aromatase, which promotes the synthesis of estradiol from testosterone, thus lowering serum T levels. Furthermore, the effect on catecholamines results in gradually improving the dissociate phenomenon of LH/FSH ratio. Therefore, TJ-68 is an effective herbal medicine for decreasing serum free-T levels and achieving pregnancy in patients with PCOD.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Study on treatment of hyperandrogenism and hyperinsulinism in polycystic ovary syndrome with Chinese herbal formula "tiangui fang"

Hou J, Yu J, Wei M. Gynecology and Obstetrics Hospital, Shanghai Medical University, Shanghai (200011). Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Aug;20(8):589-92 [Article in Chinese]

OBJECTIVE: To observe the efficacy of Chinese herbal formula "Tiangui Fang" (TGF) in hyperandrogenism and hyperinsulinism patients of polycystic ovarian syndrome (PCOS), and compare with western medicine metformin.

METHODS: Twenty-two anti-clomiphen citrite patients were divided into two treatment groups: "Tiangui Fang" (n = 10) and metformin (n = 12) for three months. Insulin response during oral glucose tolerance test and serum level of LH, FSH, testosterone (T), estradiol (E2) and waist to hip ratio (WHR), body mass index (BMI) were measured before and after treatment.

RESULTS: After treatment for three months with metformin or TGF, fasting and the integrated insulin response to the glucose load decreased. Treated by metformin 4 out of 8 patients had restoration of menstrual cyclicity and 2 of them had double phase bases body temperature (BBT). This was accompanied by lowering in serum logT/E2 but had no significant difference, the BMI, WHR and serum E2, LH:FSH ratio were not changed. Treated by TGF for three months, 6 out of 8 patients had restoration of menstrual cyclicity and double phase BBT. This was accompanied by significant lowering in serum T, logT/E2 and BMI (P < 0.05), serum LH:FSH ratio were not changed.

CONCLUSION: Both metformin and TGF can reduce the high concentration of insulin in PCOS patients and induce ovulation, the herbal formula has a better efficacy.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Clinical study of yishen jianpi yangxue tongli therapy in treating polycystic ovary syndrome

Hua L, Wu YN, Zhang JM. Department of Gynecology, Beijing Hospital of TCM, Beijing 100010. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Nov;23(11):819-22. [Article in Chinese]

OBJECTIVE: To observe the effect of Yishen Jianpi Yangxue Tongli Therapy (YJYTT) in treating polycystic ovary syndrome (PCOS) and to explore the therapeutic mechanism of YJYTT.

METHODS: One hundred and seven PCOS patients with syndrome differentiation of TCM as Pi-Shen Yang deficiency were randomly divided into two groups, the treated group (n = 76) was treated with Chinese herbal medicine, while the control group (n = 31) was treated by clomiphen. The therapeutic effect in both groups and the change of body mass index (BMI), Ferriman-Gallway (F-G) score, serum sex hormones and serum oral glucose tolerance test (OGTT) before and after treatment were observed.

RESULTS: The comparison of total effective rate between two groups was insignificantly different, but the pregnancy rate of the treated group (65.7%) was markedly higher than that of control group (25.0%, P < 0.01). Also, significant difference was shown in the aspect of BMI, F-G score, serum testosterone (T), luteinizing hormone (LH) and OGTT, etc. between the two groups (P < 0.05).

CONCLUSION: The YJYTT could markedly improve the clinical symptoms and pregnancy rate of PCOS patients, particularly showing good effect to the clomiphen resistant patients. The mechanism possibly was due to its regulation on hypothalamus-pituitary-ovarium axis and reducing the insulin resistance.

Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy

Paulus WE, Zhang M, Strehler E, El-Danasouri I, Sterzik K. Department of Reproductive Medicine, Christian-Lauritzen-Institut, Ulm, Germany. Fertil Steril. 2002 Apr;77(4):721-4.

OBJECTIVE: To evaluate the effect of acupuncture on the pregnancy rate in assisted reproduction therapy (ART) by comparing a group of patients receiving acupuncture treatment shortly before and after embryo transfer with a control group receiving no acupuncture.

DESIGN: Prospective randomized study.

SETTING: Fertility center.

PATIENT(S): After giving informed consent, 160 patients who were undergoing ART and who had good quality embryos were divided into the following two groups through random selection: embryo transfer with acupuncture (n = 80) and embryo transfer without acupuncture (n = 80).

INTERVENTION(S): Acupuncture was performed in 80 patients 25 minutes before and after embryo transfer. In the control group, embryos were transferred without any supportive therapy.

MAIN OUTCOME MEASURE(S): Clinical pregnancy was defined as the presence of a fetal sac during an ultrasound examination 6 weeks after embryo transfer.

RESULT(S): Clinical pregnancies were documented in 34 of 80 patients (42.5%) in the acupuncture group, whereas pregnancy rate was only 26.3% (21 out of 80 patients) in the control group.

CONCLUSION(S): Acupuncture seems to be a useful tool for improving pregnancy rate after ART.


Research: Atlanta Acupuncture Fertility

Decatur GA Acupuncture Infertility Atlanta

Treatment of secondary amenorrhea and oligohypomenorrhea with combined traditional Chinese and Western medicine

Ge XL. Dept. of Gynecology, Second Affiliated Hospital, Hebei Medical College, Shijiazhuang. Zhong Xi Yi Jie He Za Zhi. 1991 Nov;11(11):661-3, 645 [Article in Chinese]

This article reported the treatment of 149 cases (1087 cycles) with secondary amenorrhea and oligohypomenorrhea, including 42 cases who were treated by cycle treatment with traditional Chinese medicine (TCM) and clomiphene in comparison with clomiphene in 67 cases and/or TCM in 40 cases at the same time.

The results showed that ovulatory rate of secondary amenorrhea, calculated according to menstrual cycles, was significantly higher in the group of TCM and clomiphene than that of clomiphene or TCM (P less than 0.01). The efficacy of clomiphene was better than that of TCM (P less than 0.01). The ovulatory rate of oligohypomenorrhea was significantly increased by using TCM and clomiphene in contrast to only western medicine (P less than 0.05). The phenomena mentioned above indicate that the TCM-WM treatment has obvious advantages.

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